H. N. Nagaraja



Professor of Statistics
Professor of Medicine
Biostatistician, General Clinical Research Center
The Ohio State University


E-mail: hnn@stat.osu.edu

Office:440H Cockins Hall, 1958 Neil Avenue, Ohio State University, Columbus OH 43210-1247.
Phone: (614) 292-6072; Fax: (614) 292-2096.

Courses

Books

Recent Publications

Students

Ordered Statistical Data and Its Applications, March 2008, Aachen, Germany


Electronic Stat journals and Other Resources

International Indian Statistical Association (IISA)
 



I received my M.Sc. degree in Statistics from University of Mysore, Mysore, India, in 1974, and Ph.D. degree in Statistics from Iowa State University, Ames, in 1980.  I have been at Ohio State ever since.  I am interested in order and record statistics, general distribution theory, applied probability models, and biostatistical applications.


Courses (2007-8)

  • 821 Statistical Inference II (Winter 2008)

Books

  • Advances in Ranking and Selection, Multiple Comparisons, and Reliability - N. Balakrishnan, N. Kannan, and H. N. Nagaraja (Eds.), Birkhauser. (2005), 412 pp.
  • Order Statistics, Third Edition.  H. A. David and H. N. Nagaraja, John Wiley & Sons, 2003, 458 pp. 
  • Records. B. C. Arnold , N. Balakrishnan, and H. N. Nagaraja. John Wiley & Sons, 1998, 312 pp.
  • Statistical Theory and Applications: Papers in Honor of Herbert A. David. H. N. Nagaraja, P. K. Sen, and D. F. Morrison (Editors). Springer-Verlag, 1996, 334 pp.
  • A First Course in Order Statistics. B. C. Arnold , N. Balakrishnan, and H. N. Nagaraja. John Wiley & Sons, 1992, 304 pp. (out-of-print).

Publications

Theoretical (since 2002)

Hofmann, G. and Nagaraja, H.N.  A random power record model. Statistics and Probability Letters, Vol. 56, 2002, 345-353.

Abo-Eleneen , Z. and Nagaraja, H. N. Fisher information in an order statistic and its concomitant.   Annals of the Institute of Statistical Mathematics, 2002, Vol. 54, No. 3, 667-680.

Nagaraja H. N., Choudhary, P. K. and Matalas, N. Number of records in a bivariate sample with applications  to Missouri river flood data.  Methodology and Computing in Applied Probability, 2002, Vol. 4,  377-391.

Nagaraja H. N. and Abo-Eleneen, Z. Fisher information in Farlie-Gumbel-Morgenstern Type  Bivariate Exponential distribution. In Uncertainty and Optimality  (IIT Karagpur, India, Golden Jubilee Celebration Volume) J. C. Misra (Ed.) World Scientific, November 2002.

Hofmann, G. and Nagaraja, H. N. Fisher information in record data. Metrika, 2003, Vol. 57, No. 2, 177-193.

Linder, R. S. and Nagaraja, H. N.  Impact of censoring on sample variances in a bivariate normal model.  Journal of Statistical Planning and Inference, 2003, Vol. 114, 145-160.

Nagaraja, H. N. and Barlevy, G.  Characterizations using record moments in a random record model and applications. Journal of Applied Probability, 2003, Vol. 40, 826-833.

Nagaraja, H. N.   Functions of concomitants of order statistics.  Journal of the Indian Society for Probability and Statistics, 2003,  Vol. 7, 16-32.

H. N. Nagaraja and G. E. Baggs. (2003) On predicting the maximum component of a bivariate exponential variable. Journal of the Indian Statistical Association, Vol. 41, No. 2, 353-367.

Choudhary, P. K. and Nagaraja, H. N. (2005). Selecting the instrument closest to a gold standard.  Journal of Statistical Planning and Inference , Vol. 129, 229-237.

P. K. Choudhary and H. N. Nagaraja (2005). Measuring agreement in method comparison studies -- A review. In Advances in Ranking and Selection, Multiple Comparisons, and Reliability. N. Balakrishnan, N. Kannan, and H. N. Nagaraja (Eds.), Birkhauser, Boston, 215-244.

Mandrekar, S., Nagaraja, H. N., and Berntson, G. (2005) Statistical Modeling of the Differences Between Successive R-R Intervals. Statistics in Medicine, Vol. 24, 437-451.

H. A. David and H. N. Nagaraja. Order Statistics.  In Encyclopedia of Statistical Sciences, Revised Edition.

Balakrishnan, N. and Nagaraja, H. N. A Conversation with Herbert A. David. Statistical Science. (2004), Vol. 19, No. 4, 720-734.

Choudhary, P. K. and Nagaraja, H. N. (2005).  A two-stage procedure for selection and assessment of agreement of the best instrument with a gold standard. Sequential Analysis, Volume 24, Number 3, 237 – 257.

Choudhary, P. K. and Nagaraja, H. N. (2005). Assessing agreement using intersection-union principle.  Biometrical Journal, Vol. 47, Issue 5 , 674 – 681.

Characterizations of Probability Distributions. In Springer Handbook of Engineering Statistics, Hoang Pham (Ed.),(2006); 79-95; Springer-Verlag, London.

Order Statistics from Independent Exponential Random Variables and the Sum of the Top Order Statistics.  In Advances in Distribution Theory, Order Statistics, and Inference, N. Balakrishnan, E. Castillo, and J. M. Sarabia (Eds.), (2006), Birkhauser, Boston, 173-186.

Barlevy, G. and Nagaraja, H. N. (2006).  Characterizations in a random record model with a non-identically distributed initial record.  Journal of Applied Probability,  Vol. 43, 1119-1136.

Choudhary, P. K. and Nagaraja, H. N. (2007). Tests for assessment of agreement using probability criteria,  Journal of Statistical Planning and Inference Vol. 137,  279 – 290.

Sun, J., Nagaraja, H. N., and Reynolds, N. R. (2007). Discrete stochastic models for compliance analysis based on an ACTG study.  Biometrical Journal. (to appear)

Nagaraja H. N. and Abo-Eleneen, Z. (2007). Fisher Information in Order Statistics and Their Concomitants In Bivariate Censored Samples.  Metrika (to appear).


Applied (since 2002)

Mendell JR, Barohn RJ, Freimer ML, Kissel JT, King W, Nagaraja HN, R. Rice, W.W. Campbell, P.D. Donofrio, C.E. Jackson, R.A. Lewis, M. Shy, D.M. Simpson, G.J. Parry, M.H. Rivner, C.A. Thornton, M.B. Bromberg, R. Tandan, Y. Harati, and M.J. Giuliani.  Randomized controlled trial of IVIg in untreated chronic inflammatory demyelinating polyradiculoneuropathy.  Neurology, 2001, Vol. 56, 445-449.

Pollak CP, Tryon WW , Nagaraja HN, and Dzwonczyk, R.  How accurately does wrist actigraphy identify the states of sleep and wakefulness?  Sleep, 2001, Vol. 24, No. 8, 957-965.

Rammohan KW, Rosenberg JH , Lynn DJ, Blumenfeld AM, Pollak CP, and Nagaraja HN. Efficacy and safety of modafinil (Provigilì) for the treatment of fatigue in multiple sclerosis: a two-center phase 2 study. Journal of Neurology, Neurosurgery & Psychiatry , 2002, Vol. 72, 179-183.

Malarkey WB, Wang J, Cheney C, Glaser R, Nagaraja H.  Human lymphocyte growth hormone stimulates interferon gamma production and is inhibited by cortisol and norepinephrine. Journal of Neuroimmunology, 2002 Feb; Vol. 123(1-2), 180-187.

J-Y Cho, DHY Shen, W Yang, B Williams, TLF Buckwalter, KMD La Perle, G Hinkle, R Pozderac, R Kloos, HN Nagaraja, RF Barth, and SM Jhiang . In Vivo Imaging and Radioiodine Therapy Following Sodium Iodide Symporter Gene Transfer in Animal Model of Intracerebral Gliomas.  Gene Therapy 2002, Vol. 9, 1139-1145.

Birmingham DJ, Chen W, Liang G, Schmitt HC, Gavit K, and Nagaraja HN. A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects ;binding to C4b but not C3b.  Immunology (An Official Journal of the British Society for Immunology) Vol. 108, 531-538.

Diaz, PT, Wewers, MD, Pacht, E, Drake, J, Nagaraja, HN, Clanton, TL. Respiratory symptoms among  HIV-seropositive individuals.  Chest  Jun 2003; Vol. 123, 1977 - 1982.

Klatte, ET, Scharre, D, Nagaraja, HN, Davis, RA and Beversdorf, DQ . Combination therapy of donepezil and vitamin E in Alzheimerís disease. Alzheimer Disease and Associated Disorders, 2003,  Vol. 17, No. 2, 113-116.

Novak V, Chowdhary A, Farrar B, Nagaraja HN, Braun J, Kanard R, Novak, P, Slivka A. Altered cerebral vasoregulation in hypertension and stroke. Neurology, 2003, Vol. 60, 1657-1663.

Sahenk, Z., Serrano-Munuera, C., Chen, L., Kakabadze, I., and Nagaraja, HN.  Evidence for impaired axonal regeneration in PMP22 duplication: studies in nerve xenografts. Journal of the Peripheral Nervous System, 2003, Vol. 8, 116-127.

Collins, M. P., Periquet, M. I., Mendell, J.R., Sahenk, Z., Nagaraja, H. N. , Kissel, J. T. Nonsystemic vasculitic neuropathy. Insights from a clinical cohort.  Neurology, 2003, Vol. 61, 623-630.

D.H.Y. Shen, D.K. Marsee, J. Schaap, W. Yang, J.-Y. Cho, G. Hinkle, H.N. Nagaraja, R.T. Kloos, R.F. Barth, and S. M. Jhiang.   Effects of dose, intervention time, and radionuclide on sodium iodide symporter (NIS) targeted radionuclide therapy. Gene Therapy, 2004, Vol. 11, 161-169.

ML Prasad, NS Pellegata, Y Huang, HN Nagaraja, A de la Chapelle, RT Kloos.  Differential diagnosis of thyroid nodules using GAL3, FN1, CITED1, CK19 and HBME1 expression.  Modern Pathology (A Nature Publication), 1 Jan 2005, Vol. 18, 48-57.

Rovin BH, Song H, Birmingham DJ, Hebert LA, Yu CY, Nagaraja HN. Urine Chemokines as Biomarkers of Human Systemic Lupus Erythematosus Activity.  Journal of the American Society of Nephrology,  2005, Vol. 16(2), 467-73.

Shidham, G. B., Siddiqi, N., Beres, J. A., Logan, B., Nagaraja, H. N., Shidham, S. G., Piering, W. F. (2005). Clinical Risk Factors Associated With Bleeding  After Native Kidney Biopsy. Nephrology, (Carlton). 2005 Jun;10(3):305-10.

Rovin, BH, Tang, Y, Sun J, Nagaraja HN, Hackshaw KV, Gray L, Ladson-Wofford SE, Birmingham DJ, Yu C-Y, Spetie DN, Aziz A, Hebert LA. (2005). Clinical Significance Of Fever In The Sle Patient Receiving Steroid Therapy. Kidney International, 2005 Aug;68(2):747-59.

Beversdorf DQ, Manning SE, Hillier A, Anderson SL, Nordgren RE, Walters SE, Nagaraja HN, Cooley WC, Gaelic SE, Bauman ML. (2005).  Timing of prenatal stressors and autism. Journal of Autism and Developmental Disorders, 2005 Aug;35(4):471-8.

Sahenk, Z, Nagaraja HN, McCracken BS, King WM, Freimer ML, Cedarbaum JM and Mendell JR. (2005).  NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models and in patients.  Neurology, 2005 Sep 13;65(5):681-9.

Rovin BH, Song H, Hebert LA, Nadasdy T, Nadasdy G, Birmingham DJ, Yung Yu C, Nagaraja HN.  (2005). Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus. Kidney International 2005 Oct;68(4):1825-33.

Birmingham DJ, Gavit KF, McCarty SM, Yu CY, Rovin BH, Nagaraja HN, Hebert LA. (2006). Consumption of erythrocyte CR1 (CD35) is associated with protection against systemic lupus erythematosus renal flare. Clinical and Experimental Immunology, 2006 Feb;143(2):274-80.

Spetie DN, Nadasdy T, Nadasdy G, Agarwal G, Mauer M, Agarwal AK, Khabiri H, Nagaraja HN, Nahman NS, Hebert LA. Proposed pathogenesis of idiopathic lon pain hematuria syndrome.  American Journal of Kidney Diseases, 2006, 47(3), 419-427.

Birmingham DJ, Nagaraja HN, Rovin BH, Spetie L, Zhao Y, Li X, Hackshaw KV, Yu CY, Malarkey WB, Hebert LA (2006). Fluctuation in self-perceived stress increases risk of flare in SLE nephritis patients carrying the 5-HT1A -1019G allele. Arthritis & Rheumatism, Volume 54, Issue 10 , 3291 – 3299.

Wu YL, Higgins GC, Rennebohm RM, Chung EK, Yang Y, Zhou B, Nagaraja HN, Birmingham DJ, Rovin BH, Hebert LA, Yu CY. (2006). Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects.  Advances in experimental medicine and biology, Vol. 586, 227-247.

Leenders NY, Sherman WM, Nagaraja HN (2006). Energy expenditure estimated by accelerometry and doubly labeled water: do they agree? Medicine and Science in Sports and Exercise, 2006 Dec;38(12):2165-72.

Beversdorf DQ, Warner JL, Davis RA, Hillier, A., Sharma UK, Nagaraja HN, Bornstein RA,  Scharre DW. (2007). Problem Solving Ability in Patients with Mild Cognitive Impairment. Cognitive and Behavioral Neurology, Vol. 20, Number 1, March 2007, 44-47.

Unlu NZ, Bohn T, Francis DM,  Nagaraja HN, Clinton CK  and Schwartz SJ. (2007).  Lycopene from heat-induced cis-isomer-rich tomato sauce is more bioavailable than from all-trans-rich tomato sauce in human subjects. British Journal of Nutrition, Vol. 98, Issue 1, 140-146.

King WM, Ruttencutter R, Nagaraja HN, Matkovic V, Landoll J, Hoyle C, Mendell JR, Kissel JT (2007). Orthopedic outcomes of long-term daily corticosteroid treatment in Duchenne muscular dystrophy. Neurology, 2007, Vol. 68:1607-13.

Yang Y, Chung EK, Wu YL, Savelli SL, Nagaraja HN, Zhou B, Hebert M, Jones KN , Shu Y, Kitzmiller K,  Blanchong KA, McBride KA, Higgins GC, Rennebohm RM, Rice RR, Hackshaw KV, Roubey RAS, Grossman JM, Tsao BP, Birmingham DJ, Rovin BH, Hebert LA and Yu CY. (2007).  Gene Copy Number Variation and Associated Polymorphisms of Complement Component C4 in Human Systemic Lupus Erythematosus (SLE): Low Copy Number Is a Risk Factor for, High Copy Number Is a Protective Factor against, European American SLE Disease Susceptibility. American Journal of Human Genetics, 2007 Jun;80(6):1037-54.

Birmingham DJ, Irshaid F, Gavit KF, Nagaraja HN, Yu CY, Rovin BH, Hebert LA (2007). A polymorphism in the type one complement receptor (CR1) adds a cysteine in the C3b/C4b binding domain that inhibits ligand binding.  Molecular Immunology, 2007 Jul;44(14):3510-6.

Birmingham DJ, Rovin BH, Shidham G, Nagaraja HN, Zou X, Bissell M,  Yu CY, Hebert LA (2007).  Spot urine protein/creatinine ratio is an unreliable estimate of 24-hr proteinuria in most SLE nephritis flares.  Kidney International,  2007,  72, 865–870.

Wu YL, Savelli SL, Yang Y, Zhou B, Rovin B, Birmingham DH, Nagaraja HN, Hebert LA, Yu CY (2007). Sensitive and Specific Real-Time PCR Assays to Accurately Determine Gene Copy Number Variations (GCNVs) of Human Complement C4A, C4B, C4-Long, C4-Short and RCCX Modules: Elucidation of C4 GCNVs in 50 Consanguineous Subjects with Defined HLA Genotypes.  Journal of Immunology, 2007, 179:3012-3025.

Haddad N, Rajan J, Nagaraja HN, Agarwal AK, Hebert LA. (2007). Usual ACE Inhibitor Therapy in CKD Patients Is Associated with Lower Plasma Aldosterone Levels than Usual Angiotensin Receptor Blocker Therapy. Kidney and Blood Pressure Research,  2007 Jul 19;30(5):299-305.

Rovin DH, Birmingham DJ, Nagaraja HN, Yu C-Y,  Hebert, LA (2007). Biomarker Discovery in Human SLE Nephritis.  Bulletin of the NYU Hospital for Joint Diseases 2007;65(3):187-93 (Invited)

 Reynolds NR, Sun J, Nagaraja HN, Gifford AL, Wu AW, Chesney MA (2007). Optimizing measurement of self-reported adherence with the AIDS Clinical Trials Group Adherence Questionnaire: A cross protocol analysis.  Journal of Acquired Immune Deficiency Syndromes (to appear)

Beversdorf DQ, Sharma UK, Phillips NN, Notestine MA, Slivka AP, Friedman NM, Schneider SL, Nagaraja HN, Hillier A. (2007).  Effect of propranolol on naming in chronic Broca’s aphasia with anomia.  Neurocase (to appear).


Ph.D. Students

John A. Bunge (1989): Distribution Theory for Record Statistics from Random Record Models (Current: Department of Social Statistics, Cornell University, Ithaca, New York).

Mohammad Z. Raqab (1992): Predictors of Future Order Statistics from Type II Censored Samples (Department of Mathematics, University of Jordan, Amman, Jordan).

Geraldine E. Baggs (1994): Properties of Order Statistics from Bivariate Exponential Distributions (Ross Laboratories, Columbus, Ohio).

Glenn Hofmann (1997): A Family of General Record Models (HSBC Bank, Chicago).

Scott Linder (1998): Impact of Censoring on Sample Variances and Regression Coefficient in a Bivariate Normal Model (Ohio Weslyan University, Delaware).

Zaher A. Abo-Eleneen (2001): Fisher Information in Order Statistics and Their Concomitants (Department of Computer Science, Zagazig University, Egypt).

Pankaj K. Choudhary (2002): Assessment of Agreement and Selection of the Best Instrument in Method Comparison Studies (Dept. of Math. Sci., University of Texas at Dallas).

Sumithra J. Mandrekar (2002): Modeling of Heart Period Data and A Study of the Associated Spectral Measures (Statistician, Mayo Clinic, Rochester, Minnesota).

Yuxiao Tang (2004): Inference on Cross Correlation with Repeated Measures Data (Assistant Professor, Rush Medical School, Chicago).

Marilisa G. Gibellato (2005): Stochastic Modeling of the Sleep Process (MD, PhD; US Naval Academy, Bethesda, Maryland)

Junfeng Sun (2005): Stochastic Models for Compliance Analysis and Applications (Assistant Professor, University of Nebraska Medical School, Omaha).

Jesse C. Frey (2005): Inference Procedures Based on Order Statistics (Assistant Professor, Villanova University, Philadelphia)

Xiaobai Li (2006): Stochastic Models for MRI Lesion Count Sequences from Patients with Relapsing Remitting Multiple Sclerosis (Senior Consulting Biostatistician, Center for Biostatistics, Ohio State University)

Yanxing Zhao (2006): Parametric Inference from Window Censored Renewal Process Data (Statistician, Novartis Pharamaceuticals, New Jersey)

Qinying He (2007): Inference on Correlation from Incomplete Bivariate Samples (Assistant Professor, Research Institute of Economics & Management, Southwest University of Finance and Economics, Chengdu, China)


Updated: October 29, 2007